論文


2024年

Otsuka S, Matsuzaki R, Kakimoto S, Tachibe Y, Kawatani T, Takada S, Tani A, Nakanishi K, Matsuoka T, Kato Y, Inadome M, Nojima N, Sakakima H, Mizuno K, Matsubara Y, Maruyama I. Ninjin'yoeito reduces fatigue-like conditions by alleviating inflammation of the brain and skeletal muscles in aging mice.PLoS One. 2024 May 20;19(5):e0303833.

Otsuka S, Kikuchi K, Takeshita Y, Takada S, Tani A, Sakakima H, Maruyama I, Makizako H.Relationship between physical activity and cerebral white matter hyperintensity volumes in older adults with depressive symptoms and mild memory impairment: a cross-sectional study.Front Aging Neurosci. 2024 Feb 13;16:1337397.

2023年

Norimatsu K, Nakanishi K, Ijuin T, Otsuka S, Takada S, Tani A, Matsuzaki R, Matsuoka T, Sakakima H. Effects of low-intensity exercise on spontaneously developed knee osteoarthritis in male senescence-accelerated mouse prone 8.Arthritis Res Ther. 2023 Sep 14;25(1):168. doi: 10.1186/s13075-023-03162-z.

則松 貢輔, 中西 和毅, 柿元 翔吾, 野島 菜央, 谷 明, 松崎 凌真, 松岡 輝樹, 稲留 真輝, 加藤 夕貴, 立部 勇汰, 高田 聖也, 大塚 章太郎, 角園 恵, 榊間 春利:トレッドミル運動と水泳が老化促進マウスの自然発症型変形性膝関節症に及ぼす影響.基礎理学療法学2023

榊間春利, 大塚章太郎,谷明: (特集)人参養栄湯による老化促進マウスの身体的フレイルに及ぼす影響, Prog.Med. 43:509〜514, 2023

中西和毅, 中村壮志, 小林明日香, 松野竜工, 下村珠美, 宮﨑雅司, 田邊 史, 井㞍幸成, 榊間春利: 腰椎前外側椎体間固定術(OLIF)と後方椎体固定を併用した腰椎変性側弯症患者の腹部筋再教育に着目した術後理学療法. 理学療法かごしま1 : 38-44, 2022

Nakanishi K, Norimatsu K, Tani A, Matsuoka T, Matsuzaki R, Kakimoto S, Nojima N, Tachibe Y, Kato Y, Inadome M, Kitazato R, Otsuka S, Takada S, Sumizono M, Sakakima H.Effects of early exercise intervention and exercise cessation on neuronal loss and neuroinflammation in a senescence-accelerated mouse prone 8.Neurosci Lett. 2023 May 12;808:137297. doi: 10.1016/j.neulet.2023.137297. Neurosci Lett. 2023 Jun 21;808:137297.

Otsuka S, Itashiki Y, Tani A, Matsuoka T, Takada S, Matsuzaki R, Nakanishi K, Norimatsu K, Tachibe Y, Kitazato R, Nojima N, Kakimoto S, Kikuchi K, Maruyama I, Sakakima H. Effects of different remote ischemia perconditioning methods on cerebral infarct volume and neurological impairment in rats.Sci Rep. 2023 Feb 7;13(1):2158. doi: 10.1038/s41598-023-29475-2.

2022年


Tani A, Sakakima H, Otsuka S, Mizuno K, Nakanishi K, Norimatsu K, Takada S, Matsuoka T, Matsuzaki R, Nakakogawa T, Maruyama I. Stimulation of functional recovery via neurorepair mechanisms by the traditional Japanese Kampo medicine, Ninjin'yoeito, and physical exercise in a rat ischemic stroke model.J Ethnopharmacol. 2022 Nov 16:115927. doi: 10.1016/j.jep.2022.115927.

Otsuka S, Fukumaru K, Tani A, Takada S, Kikuchi K, Norimatsu K, Matsuzaki R, Matsuoka T, Sakakima H, Omiya Y, Mizuno K, Matsubara Y, Maruyama I.Analysis of the Effects of Ninjin'yoeito on Physical Frailty in Mice.Int J Mol Sci. 2022 Sep 23;23(19):11183. doi: 10.3390/ijms231911183.

Sumizono M, Yoshizato Y, Yamamoto R, Imai T, Tani A, Nakanishi K, Nakakogawa T, Matsuoka T, Matsuzaki R, Tanaka T, Sakakima H.
Mechanisms of Neuropathic Pain and Pain-Relieving Effects of Exercise Therapy in a Rat Neuropathic Pain Mode. J Pain Res, 2022, 15:1925-1938.

Seiya Takada, Kentaro Setoyama, Kosuke Norimatsu, Shotaro Otsuka, Kazuki Nakanishi, Akira Tani, Tomomi Nakakogawa, Ryoma Matsuzaki, Teruki Matsuoka, Harutoshi Sakakima, Salunya Tancharoen, Ikuro Maruyama, Eiichiro Tanaka, Kiyoshi Kikuchi, Hisaaki Uchikado.
E8002 Reduces Adhesion Formation and Improves Joint Mobility in a Rat Model of Knee Arthrofibrosis. Int. J. Mol. Sci. 2022 Jan 22. doi: 10.3390/ijms23031239.

Keisuke Natsume, Harutoshi Sakakima, Kentaro Kawamura, Akira Yoshida, Shintaro Akihiro, Hajime Yonezawa, Koji Yoshimoto, Megumi Shimodozono.
Factors Influencing the Improvement of Activities of Daily Living during Inpatient Rehabilitation in Newly Diagnosed Patients with Glioblastoma Multiforme. J Clin Med. 2022 Jan 14. doi: 10.3390/jcm11020417.


2021年

Otsuka S, Setoyama K, Takada S, Nakanishi K, Terashi T, Norimatsu K, Tani A, Sakakima H, Maruyama I, Tancharoen S, Tanaka E, Kikuchi K.
Preconditioning Exercise in Rats Attenuates Early Brain Injury Resulting from Subarachnoid Hemorrhage by Reducing Oxidative Stress, Inflammation, and Neuronal Apoptosis. Mol Neurobiol. 2021 Aug 9. doi: 10.1007/s12035-021-02506-7.

Otsuka S, Sakakima H, Tani A, Nakanishi K, Takada S, Norimatsu K, Maejima H, Maruyama I. Effects of detraining on preconditioning exercise-induced neuroprotective potential after ischemic stroke in rats
Brain Struct Funct. 2021 Jun 10. doi: 10.1007/s00429-021-02317-5.

シリーズ「疾病予防の基礎研究と臨床応用」
高齢脊椎変性疾患の手術治療と予防リハビリテーション
宮﨑 雅司, 田邊 史, 榊間 春利 2021 年 48 巻 2 号 p. 236-241

Nakanishi K, Sakakima H, Norimatsu K, Otsuka S, Takada S, Tani A, Kikuchi K.
Effect of low-intensity motor balance and coordination exercise on cognitive functions, hippocampal Aβ deposition, neuronal loss, neuroinflammation, and oxidative stress in a mouse model of Alzheimer's disease
Exp Neurol. 2021 Mar;337:113590.


2020年

Sakakima H, Takada S, Norimatsu K, Otsuka S, Nakanishi K, Tani A.
Diurnal Profiles of Locomotive and Household Activities Using an Accelerometer in Community-Dwelling Older Adults with Musculoskeletal Disorders: A Cross-Sectional Survey
Int J Environ Res Public Health. 2020 Jul 24;17(15):5337

Takada S, Sakakima H, Matsuyama T, Otsuka S, Nakanishi K, Norimatsu K, Itashiki Y, Tani A, Kikuchi K
Disruption of Midkine gene reduces traumatic brain injury through the modulation of neuroinflammation
J Neuroinflammation. 2020 Jan 29;17(1):40

Kikuchi K, Setoyama K, Takada S, Otsuka S, Nakanishi K, Norimatsu K, Tani A, Sakakima H, Kawahara KI, Hosokawa K, Kiyama R, Sumizono M, Tancharoen S, Maruyama I, Hattori G, Morioka M, Tanaka E, Uchikado H
E8002 Inhibits Peripheral Nerve Adhesion by Enhancing Fibrinolysis of l-Ascorbic Acid in a Rat Sciatic Nerve Model
Int J Mol Sci. 2020 Jun 1;21(11):3972

Inoue T, Okamura M, Kitahara M, Takamatsu Y, Sakakima H, Maejima H.
Exercise Plus Pharmacological Neuromodulation of Synaptic Inhibition Enhance Motor Function Recovery After Ischemic Stroke.
Neuroscience. 2020 Mar 15;430:12-24. doi: 10.1016/j.neuroscience.2020.01.012. PMID: 31982464

2019年 

Terashi T, Otsuka S, Takada S, Nakanishi K, Ueda K, Sumizono M, Kikuchi K, Sakakima H.
Neuroprotective effects of different frequency preconditioning exercise on neuronal apoptosis after focal brain ischemia in rats
Neurol Res. 2019 Jun;41(6):510-518

Otsuka S, Sakakima H, Terashi T, Takada S, Nakanishi K, Kikuchi K.
Preconditioning exercise reduces brain damage and neuronal apoptosis through enhanced endogenous 14-3-3γ after focal brain ischemia in rats
Brain Struct Funct. 2019 Mar;224(2):727-738

谷 明, 藤川 寿史, 中西 和毅, 高田 聖也, 則松 貢輔, 大塚 章太郎, 宮崎 雅司, 榊間 春利
腰椎術後患者の安静、Draw-in、頭部挙上による側腹筋筋厚変化
形態・機能 2019年18巻1号 p.2-8

Sakakima H.
Endogenous neuroprotective potential due to preconditioning exercise in stroke.
Phys Ther Res. 2019 Sep 6;22(2):45-52.

2018年 

Sumizono M, Sakakima H, Otsuka S, Terashi T, Nakanishi K, Ueda K, Takada S, Kikuchi K
The effect of exercise frequency on neuropathic pain and pain-related cellular reactions in the spinal cord and midbrain in a rat sciatic nerve injury model
J Pain Res. 2018 Feb 7;11:281-291

Haseba S, Sakakima H, Nakao S, Ohira M, Yanagi S, Imoto Y, Yoshida A, Shimodozono M
Early postoperative physical therapy for improving short-term gross motor outcome in infants with cyanotic and acyanotic congenital heart disease
Disabil Rehabil. 2018 Jul;40(14):1694-1701

Akihiro S, Taira Y, Maeda K, Natsume K, Sakakima H.
Feasibility and effectiveness of home-based exercise programs on physical performance and health-related quality of life of the older people dwelling on an isolated, doctor-less island.
Geriatr Gerontol Int. 2018 Sep;18(9):1313-1317. doi: 10.1111/ggi.13459. PMID: 29984893

Kikuchi K, Setoyama K, Tanaka E, Otsuka S, Terashi T, Nakanishi K, Takada S, Sakakima H, Ampawong S, Kawahara KI, Nagasato T, Hosokawa K, Harada Y, Yamamoto M, Kamikokuryo C, Kiyama R, Morioka M, Ito T, Maruyama I, Tancharoen S
Uric acid enhances alteplase-mediated thrombolysis as an antioxidant
Sci Rep. 2018 Oct 26;8(1):15844

Kikuchi K, Setoyama K, Terashi T, Sumizono M, Tancharoen S, Otsuka S, Takada S, Nakanishi K, Ueda K, Sakakima H, Kawahara KI, Maruyama I, Hattori G, Morioka M, Tanaka E, Uchikado H.
Application of a Novel Anti-Adhesive Membrane, E8002, in a Rat Laminectomy Model
Int J Mol Sci. 2018 May 18;19(5):1513

2017年

Kikuchi K, Setoyama K, Kawahara KI, Nagasato T, Terashi T, Ueda K, Nakanishi K, Otsuka S, Miura N, Sameshima H, Hosokawa K, Harada Y, Shrestha B, Yamamoto M, Morimoto-Yamashita Y, Kikuchi H, Kiyama R, Kamikokuryo C, Tancharoen S, Sakakima H, Morioka M, Tanaka E, Ito T, Maruyama I
Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis
Oxid Med Cell Longev. 2017;2017:6873281

Tanaka K, Sakakima H, Hida K, Hatanaka K, Ijiri K.
A Case of C5 Vertebral Chordoma in a 73-Year-Old Patient with More Than 8 Years of Follow-Up after Total Piecemeal Spondylectomy.
Case Rep Orthop. 2017;2017:3284131. doi: 10.1155/2017/3284131.PMID: 29138702


2016年

Haseba S, Sakakima H, Kubozono T, Nakao S, Ikeda S
Combined effects of repeated sauna therapy and exercise training on cardiac function and physical activity in patients with chronic heart failure
Disabil Rehabil. 2016;38(5):409-15.

中尾 周平, 榊間 春利 , 長谷場 純仁, 吉田 輝 , 窪薗 琢郎, 窪田 佳代子
重症肺動脈性肺高血圧症患者に対する理学療法の有効性の検討
理学療法ジャーナル 50巻5号 pp.532-535

中尾 周平, 榊間 春利 , 長谷場 純仁, 吉田 輝 , 窪薗 琢郎, 窪田 佳代子
肺静脈閉塞症患者に対する理学療法介入が運動耐容能やADLに及ぼす影響
総合リハビリテーション 44巻7号 pp.625-628

Otsuka S, Sakakima H, Sumizono M, Takada S, Terashi T, Yoshida Y
The neuroprotective effects of preconditioning exercise on brain damage and neurotrophic factors after focal brain ischemia in rats
Behav Brain Res. 2016 Apr 15;303:9-18.

Shimada H, Otero M, Tsuchimochi K, Yamasaki S, Sakakima H, Matsuda F, Sakasegawa M, Setoguchi T, Xu L, Goldring MB, Tanimoto A, Komiya S, Ijiri K
CCAAT/enhancer binding protein β (C/EBPβ) regulates the transcription of growth arrest and DNA damage-inducible protein 45 β (GADD45β) in articular chondrocytes
Pathol Res Pract. 2016 Apr;212(4):302-9


2014年 

Ikutomo M, Sakakima H, Matsuda F, Yoshida Y
Midkine-deficient mice delayed degeneration and regeneration after skeletal muscle injur
Acta Histochem. 2014 Mar;116(2):319-26

Kamimura A, Sakakima H, Tsutsumi F, Sunahara N
Preoperative predictors of ambulation ability at different time points after total hip arthroplasty in patients with osteoarthritis
Rehabil Res Pract. 2014;2014:861268

Yoshida Y, Sakakima H, Matsuda F, Ikutomo M.
Midkine in repair of the injured nervous system.
Br J Pharmacol. 2014 Feb;171(4):924-30. doi: 10.1111/bph.12497.PMID: 24460674

2013年 

Kamimura A, Sakakima H, Miyazaki M, Sakasegawa M, Ijiri K, Sunahara N, Matsuda T
Pelvic Inclination Angle and Hip Abductor Muscle Strength after Total Hip Arthroplasty
Journal of Physical Therapy Science. 2013 年 25 巻 2 号 p. 215-219

Sakakima H, Ijiri K, Matsuda F, Tominaga H, Biwa T, Yone K, Sankai Y.
A newly developed robot suit hybrid assistive limb facilitated walking rehabilitation after spinal surgery for thoracic ossification of the posterior longitudinal ligament: a case report.
Case Rep Orthop. 2013;2013:621405. doi: 10.1155/2013/621405. PMID: 24369516

2012年

Sakakima H, Khan M, Dhammu TS, Shunmugavel A, Yoshida Y, Singh I, Singh AK.
Stimulation of functional recovery via the mechanisms of neurorepair by S-nitrosoglutathione and motor exercise in a rat model of transient cerebral ischemia and reperfusion.
Restor Neurol Neurosci. 2012;30(5):383-96. doi: 10.3233/RNN-2012-110209.PMID: 22717646

2011年

Matsuda F, Sakakima H, Yoshida Y
The effects of early exercise on brain damage and recovery after focal cerebral infarction in rats
Acta Physiol (Oxf). 2011 Feb;201(2):275-87

Miyazaki M, Sakakima H, Goto T, Kiyama R, Matsuzaki T, Ijiri K, Yoshida Y
Isokinetic trunk and knee muscle strengths and gait performance in walking patients with T-cell lymphotropic virus type 1-associated myelopathy/ tropical spastic paraparesis (HAM/TSP)
J Jpn Phys Ther Assoc. 2011;14(1):19-26.

2009年

Sakakima H, Yoshida Y, Yamazaki Y, Matsuda F, Ikutomo M, Ijiri K, Muramatsu H, Muramatsu T, Kadomatsu K.
Disruption of the midkine gene (Mdk) delays degeneration and regeneration in injured peripheral nerve.
J Neurosci Res. 2009 Oct;87(13):2908-15. doi: 10.1002/jnr.22127.PMID: 19437545

2006年 

Sakakima H, Kamizono T, Matsuda F, Izumo K, Ijiri K, Yoshida Y
Midkine and its receptor in regenerating rat skeletal muscle after bupivacaine injection
Acta Histochem. 2006;108(5):357-64

科研費取得状況

研究代表者:榊間 春利
2024-2028 科学研究費助成事業:基盤研究B
コンディショニングによる脳保護を考慮した予防リハビリテーションの構築

2020-2024 科学研究費補助金:基盤研究B
脳梗塞前後のコンディショニングによる神経保護機序の解明と脳卒中リハビリへの応用

2017-2020 科学研究費補助金:基盤研究C
脳梗塞発症前・後の運動療法による機能回復と神経保護メカニズム解明に関する研究

2014-2017 科学研究費補助金:基盤研究C
脳梗塞後の運動療法による神経保護と脳内生理活性物質の変化に関する研究

研究代表者:中西 和毅
2023-2026 科学研究費助成事業:若手研究
遠隔虚血コンディショニングによる認知症予防の新規介入方法の開発と作用機序の解明

2020-2022 科学研究費助成事業:特別研究員奨励費
予防的運動介入がグリア細胞分極や神経生存と行動学的評価に与える影響の解明

研究代表者:大塚 章太郎
2019-2020 科学研究費補助金:研究活動スタート支援
遠隔虚血プレコンディショニングと運動療法の併用による神経保護効果獲得に関する研究